NOVEL APPROACHES TO LUNG CANCER PREVENTION: MODULATING EGFR PATHWAY WITH NATURAL COMPOUNDS
ABSTRACT According to the World Health Organization(WHO), lung carcinoma is the most common cause of cancer-related death in both developed and developing countries. It can generally be divided into two subtypes: Non-small cell lung cancer (NSCLC) accounting approximately 85% in all tumor cases, and Small cell lung cancer(SCLC) . Epidermal Growth Factor Receptor(EGFR), a protein present on the surface of cells and are crucial for Cell growth, proliferation, survival and differentiation. It is a receptor Tyrosine Kinase when gets muted lead to abnormal signaling that result in uncontrolled cell growth, proliferation and necrosis . EGFR mutation prevalence appears to be consistent across all stages of NSCLC. Due to the severe side effects and acquiring multi-resistance, its clinical treatment has always been difficult. Clinical efficiency of EGFR inhibitors as gefitinib, afatinib, and Osimertinib is often limited by resistance and show several side effects like diarrhoea, hepatoto...