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NOVEL APPROACHES TO LUNG CANCER PREVENTION: MODULATING EGFR PATHWAY WITH NATURAL COMPOUNDS

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ABSTRACT According to the World Health Organization(WHO), lung carcinoma is the most common cause of cancer-related death in both developed and developing countries. It can generally be divided into two subtypes: Non-small cell lung cancer (NSCLC) accounting approximately 85% in all tumor cases, and Small cell lung cancer(SCLC) . Epidermal Growth Factor Receptor(EGFR), a protein present on the surface of cells and are crucial for Cell growth, proliferation, survival and differentiation. It is a receptor Tyrosine Kinase when gets muted lead to abnormal signaling that result in uncontrolled cell growth, proliferation and necrosis . EGFR  mutation prevalence appears to be consistent across all stages of NSCLC. Due to the severe side effects and acquiring multi-resistance, its clinical treatment has always been difficult. Clinical efficiency of EGFR inhibitors as gefitinib, afatinib, and Osimertinib is often limited by resistance and show several side effects like diarrhoea, hepatoto...
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SELF LOVE

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SELF LOVE   means love for yourself  .The way you are you accept yourself and have a positive approach to become better . This is basically establishing a balance between your flaws and strength ,success and failure . Failing to achieve a balance across every area of your life can leave you exhausted and many unpleasant emotion such as guilt . Self love consists of two essential elements that must be balance if one wishes to live a harmonious life : 1. Unconditional love towards yourself without any transformation .You appreciate yourself where you are and who you are . 2. Encouraging yourself for growth.Take action that improves you and inner self .Self love also means that you deserve better and not settling on mediocrity .So take action to be better each day. True self love can be present in anything that adds value to your life accepting your flaws being content with who you are .Self love is empowerment and liberation.
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ALGINATE : THE BIOPOLYMER OF FUTURE FOR THE OCULAR DRUG DELIVERY SYSTEM

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 Ab stract One of the most susceptible and vital organs in our body is the eye, but due to various ocular barriers like tear turnover, nasolacrimal drainage, blood retinal barriers etc. possess a great challenge for the ocular delivery of drugs. Alginate, a natural polysaccharide obtained from marine brown seaweeds and various bacterial sources carries a great potential for the novel ocular drug delivery formulations. Alginate which is already a renowned excipient in other fields of drug delivery and due to its various advantages like mucoadhesive behaviour, biodegradable and non-toxic nature makes it a perfect candidate for this delivery route. The ability of instant gelation results into higher ocular residence time and enhanced ocular drug bioavailability which means lower frequency of ocular drug administration. The various alginate based ocular drug delivery formulations include in situ gels, microparticles, nanoparticles, ocular films, ocular inserts, ocular gels and biodegra...
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Personalized Treatment Of Cancer by the Application of Artificial Intelligence (AI)

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Abstract Cancer is a major medical problem worldwide .Due to its high heterogeneity, the use of same drugs or surgical methods in patients with same tumor may have different curative effects leading to need for more accurate treatment methods for tumors & personalized treatment for patients. And here comes the role of Artificial Intelligence(AI). AI has the availability   of high dimensionality datasets coupled with advances in high performance computing, as well as deep learning architecture has lead to an explosion of AI use in various aspects of oncology research. In addition , AI can find new biomarkers from data to assist tumor screening, detection, diagnosis, treatment and prognosis prediction ,so as to providing the best treatment for individual patients and improving their clinical outcomes. Introduction Cancer is a severe threat to human health with a high mortality and a rising incidence rate. the heterogeneity of tumors is high, which can create great challenges in...
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Sleeping Pattern And Atherosclerosis.

  We all know sleep has connection with cardiovascular diseases but the less people know Sleep cycle has been associated with Atherosclerosis. The Research carried by MESA( Multi Ethical Study of Atherosclerosis)  on 2032 men having mean age of 68 years.  For 7 days , participants underwent assessment of coronary artery Calcium , Carotid plaque presence , Carotid Intima - media thickness and ankle brachial index . Participants with more regular sleep duration is compared with  people having less sleep duration. Results shows that participants with highly more irregular sleep duration were more likely to have high Coronary Artery Calcium burden & abnormal Brachial Index , making them more prone to Atherosclerosis. So whenever you are going to bed late without any reasons ,remember you are pushing yourself towards major health issues.  Source:   Originally published 15 Feb 2023 https://doi.org/10.1161/JAHA.122.027361 Journal of the American Heart Associat...
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Pharmacy:  It is derived from word "pharmakon"  which means Remedy . It is a branch of science that deals with the discovery ,production, disposal and uses of drug for having a pharmaceutical action on body.😊😊 Types of pharmacy : 1) Community pharmacy - The most traditional and common form of pharmacy in which pharmacist provides advice and respective drugs to the community who are needy. 2) Hospital pharmacy - In this there is a collaboration between pharmacist and other medical or health professionals for providing the best drugs to patients. 3) Clinical pharmacy - This type of pharmacy involves provision of patients case with use of medication to optimize health outcomes of patients. 4) Industrial pharmacy - This type of pharmacy involves the manufacturing ,development , marketing & distribution of drugs products including quality assurance of these activities . 5) Compounding Pharmacy - It is the   most traditional type of pharmacy for making drugs prescrib...
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